E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors.
نویسندگان
چکیده
Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncation led to the persistence of expression in the absence of E4, thus eliminating the ORF3 requirement.
منابع مشابه
Effect of the E4 region on the persistence of transgene expression from adenovirus vectors.
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عنوان ژورنال:
- Journal of virology
دوره 73 8 شماره
صفحات -
تاریخ انتشار 1999